NIH R01 · 2024
Endothelial PHD2 in hypertensive vascular remodeling
Summary: Arterial stiffness is the center feature of hypertension and has significant impact upon disease etiology and outcomes. So far, there is no cure for hypertensive arterial stiffness. Therefore, it is urgent to identify potential therapeutic targets that can reduce hypertensive arterial stiffness. Emerging evidence indicates that pericyte is a novel target of angiogenesis and vascular remodeling. Pericytes are a subpopulation of mesenchymal stem cells which can differentiate into osteoblasts, vascular smooth muscle cells (VSMCs) and fibroblasts. Pericytes promotes fibrosis formation via pericyte-(myo)-fibroblast transition (PFT). Pericyte also has been shown to differentiate into…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.