NIH R01 · 2024
Impacts of transcription elongation on cardiac gene regulation during homeostasis and regeneration
Project Summary Heart failure is a major cause of death in the US, contributing significantly to the burden of the healthcare system every year. Despite the heterogeneity of the causes of heart failure, the heart undergoes gene expression changes during failure resulting in structural and functional defects. Our long-term goal is to understand the transcriptional regulatory mechanisms that sustain the structure and function of the heart in homeostasis and that can induce cardiac protective effects or promote cardiac repair upon injury. In this application, we will use the transcription regulator Rtf1 as a point of entry to address this critical question in cardiac biology. Critical roles…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.