NIH R01 · 2025
Monitoring Autophagy in the Heart and in Tumors Treated with Potentially Cardiotoxic Chemotherapy
The treatment of cancer has been revolutionized by the development of targeted and immune-based therapies. However, many of these new therapies, as well as established ones such as doxorubicin, can damage the heart and cause severe heart failure. A growing body of evidence suggests that perturbations in cardiomyocyte autophagy may play a central role in chemotherapy-induced heart failure, and the ability to image this process in vivo could provide important insights. We have recently developed an autophagy-detecting nanoparticle (ADN) and have used this agent to image autophagy in the heart during chemotherapy with doxorubicin and dasatanib. The core of the agent consists of ferumoxytol, an…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.