Chen Lab

Research focus

NIH R01 · 2025

Pesticide Use and Markers of ADRD Neurodegeneration among US Farmers

Abstract Many pesticides are neurotoxic, and high exposures may have long-term neurodegenerative consequences. However, empirical evidence on the association between pesticides and Alzheimer’s disease and related dementias (ADRD) is preliminary and inconsistent. This project will identify links between pesticide exposure and markers across the ADRD neurodegeneration continuum, from preclinical biomarkers to clinical diagnosis. The study will be conducted among rural farmers, the group with particularly high pesticide exposure. The central hypothesis is that high pesticide exposure will increase the risk of ADRD neurodegeneration. This project will leverage 30 years of environmental health…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.