Chen Lab

Research focus

NIH R01 · 2024

Efficient IBD mapping for Alzheimer's Disease and related brain imaging phenotypes

PROJECT SUMMARY/ABSTRACT Alzheimer’s Disease (AD) is a highly heritable complex human disease, but only a limited number of its genetic risk factors have been identified. In this project, we propose to leverage identical-by-descent (IBD) segments, which are expected to better tag haplotype effects and provide complementary genetic information to additively coded genotypes that are commonly used in genome-wide association studies, in the genetic association mapping for AD and related brain imaging endophenotypes. In Aim 1, we will develop the statistical and computational framework for efficient genetic association mapping using IBD segments in large samples. In Aim 2, we will apply IBD…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.