NIH R01 · 2025
Spatially Resolved Molecular Measurement of Biomolecular Condensates
PROJECT SUMMARY Biomolecular condensates are diverse and abundant membrane-less organelles that partition the intracellular environment into functionally distinct compartments containing specific sets of molecules and reactions. Biomolecular condensates participate in various essential housekeeping, stress-response, or cell type-specific processes. Furthermore, an increasing number of studies have linked the physiological state of a cell or the spatial locations of condensates in a cell with the composition of the condensates. Thus, to understand the functions of biomolecular condensates, it is important to know how the molecular content in the condensates change in health vs. disease or in…
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