NIH R01 · 2025
The molecular mechanism of Siglec-E in bacterial clearance
Sepsis is a systemic inflammatory response syndrome initiated by infection. Most cases of septic shock are caused by Gram-negative bacteria, including Escherichia coli (E. coli), which remains one of the most common pathogens leading to sepsis. Understanding the mechanisms by which the mammalian immune system differentially responds to infection by Gram-negative and Gram-positive bacteria will place us in a better position to treat or prevent sepsis. Members of the sialic acid-binding immunoglobulin-like lectin family (Siglecs) are cell surface receptors that negatively regulate the response to infection by binding or taking up sialylated pathogens; however, most pathogens are not…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.