NIH R01 · 2025
Novel Integrative Analysis of Microbiome and Host Genetics in Childhood Asthma Research
Project Summary Childhood asthma poses a significant public health burden due to its high prevalence, associated healthcare costs, and long-term impacts on children's health and development. The human microbiome has been associated with asthma phenotypes, endotypes, and disease severity, positioning it as a potential therapeutic target for asthma prevention and control, particularly since the microbiome is inherently modifiable. We recently assembled the largest and most geographically diverse datasets containing infant nasal and gut microbiomes, along with host genetics data, from multiple birth cohorts within the NIH-funded Children’s Allergy and Asthma Data Repository (CADRE). This study…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.