NIH R01 · 2025
PROJECT ABSTRACT Inherited genetic variation is a key component in the etiology of prostate cancer (PCa). More than 450 common single nucleotide variants (SNVs) for PCa have been identified in large-scale multi-ancestry genome-wide association studies (GWAS) and rare pathogenic SNVs in >30 PCa candidate genes have been implicated across ancestry populations. Although somatic copy number alterations are commonly observed in prostate tumors and predict poor outcomes, studies are limited in evaluating the contribution of germline copy number variations (CNVs) to PCa risk, due to the technical challenges of detecting germline CNVs from genotype and sequencing data. CNVs, the deletion and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.