NIH R01 · 2025
Innate and Adaptive Immunity in the Pathogenesis of Glaucoma
Innate and Adaptive Immune Responses in the Pathogenesis of Glaucoma Glaucoma is a globally unmet medical challenge and a leading cause of irreversible blindness. Elevated intraocular pressure (IOP) is a major risk factor of glaucoma; yet, clinically it is neither required nor sufficient to cause neuronal damage. The mechanisms underlying glaucomatous neurodegeneration are not fully understood. Recently, we have provided the first convincing evidence demonstrating an immune mechanism underlying neurodegeneration in glaucoma. We showed in both the inducible and inherited glaucomatous mouse models that elevated IOP induced upregulation of heat shock proteins (HSPs), retinal microglial…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.