NIH R01 · 2024
Therapeutic targeting of Wnt signaling in cancer
Project Summary/Abstract The overarching goal of our research program is to develop small-molecule anticancer drugs. We focus herein on a new chemical method to control aberrant Wnt/β-catenin signaling that drives tumorigenesis and metastasis of many cancers, in particular, colorectal cancer (CRC). CRC affects about 4% of the population and caused ~60,000 deaths in 2021. Despite decades of effort, drugging this oncogenic pathway has not been successful. In 2009, we reported for the first time that Wnt/β-catenin signaling can be intercepted by small molecules. Catalytic inhibition of tankyrases prevents the turnover of the Axin, which leads to a rapid accumulation of Axin. The accumulated…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.