NIH R01 · 2025
Structure, function, and mechanobiology of a compression-sensitive cell-cell junction
Project Description and Summary The goal of this proposal is to characterize a newly identified cadherin-mediated cell-cell junction, and understand the contexts in which it functions. The cooperation between adhesions and mechanical forces is a central regulator of many developmental and homeostatic processes that has been studied for over half a century across a wide variety of biological contexts. In particular, the assembly of junctional complexes triggered by mechanical tension – a phenomenon known as adhesion strengthening – is widely conserved across a diverse range cell-matrix and cell-cell adhesion receptors, such that it has been suggested that it may be the only type of response…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.