NIH R01 · 2025
Stromal Effects in Head and Neck Squamous Cell Carcinoma
Squamous cell carcinoma of the head and neck (HNSCC) is a complex disorder that contains multiple cell populations, making it is difficult to study the nature and cellular function and delineate relationship among subpopulations. The analysis of global gene expressions in single cell level has evolved at an astounding pace in the past few years, and now reaching a sophisticated level to solve heterogeneity in complex organs. To understanding the in vivo tumor microenvironment, a large scale (~10,000 cells) single cell gene expression assay can elucidate transitional states and delineate relationships among subpopulations. The goals of this proposal are to characterize a distinct population…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.