NIH R01 · 2025
Vaginal Microbiome, Inflammatory Mediators, Metabolome, and Dysmenorrhea Symptom-based Phenotypes
PROJECT SUMMARY Dysmenorrhea is a prevalent pain condition and a risk factor for developing other chronic pain conditions. Dysmenorrhea experiences vary significantly among individual women. Some women are symptom-free, and those with symptoms fall into three dysmenorrhea symptom phenotypes: mild localized pain, severe localized pain, and multiple severe symptoms. The mechanisms underlying this individual variation remain incompletely understood, creating barriers for expanding and personalizing dysmenorrhea treatment options. Given the role of the vaginal microbiota in inflammation and female reproductive health and the proof-of-concept data linking vaginal microbiota and dysmenorrhea…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.