Chen Lab

Louisiana State Univ A&m Col Baton Rouge

BIOLOGY

Baton Rouge · United States

NIH-funded
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Research focus

NIH R01 · 2025

SSLs immune manipulation in S aureus colonization, infection, and a potential therapy against pneumonia

PROJECT SUMMARY / ABSTRACT Staphylococcus aureus associated pneumonia accounts for an estimated 50,000 staphylococcal infections annually in the United States. S. aureus is one of the leading etiologic agents of ventilator-associated pneumonia in the intensive care environment. S. aureus pneumonia has a high rate of mortality due to the prevalence of antibiotic resistance and lack of an effective vaccine. Although S. aureus colonization (30% of humans) is strongly associated with higher risks for clinical infections, most colonized individuals will not experience S. aureus infections, suggesting that S. aureus maintains a dedicated balance with the host. Our knowledge gaps between S. aureus…

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