NIH R01 · 2024
HIV-1 membrane fusion and inhibition
Summary Virus entry begins with the first encounter between the virus and the cell surface and ends with delivery of the contents of the virus into the host cell. HIV-1 membrane fusion is the first key delivery step, mediated by the virus-encoded envelope glycoprotein [Env; trimeric (gp160)3 cleaved to (gp120/gp41)3], which belongs to the group of class I viral fusion proteins including influenza hemagglutinin, SARS-CoV-2 spike protein and Ebola glycoprotein. A mature Env spike has three copies each of noncovalently-associated receptor-binding subunit gp120 and fusion subunit gp41. Sequential binding of gp120 to the primary receptor CD4 and a coreceptor (chemokine receptor CCR5 or CXCR4)…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.