NIH R01 · 2025
Lineage Progression of Cortical Neural Stem Cells
Formation of functional neural circuits depends on the proper generation of different neuronal and glial cell types in the correct numbers and order. In the developing mammalian central nervous system, multipotent neural stem cells initially produce neurons, followed by glia. The cerebral cortex is the brain region that best exemplifies this developmental theme. In the developing cortex, multipotent neural stem cells, known as the radial glial cells (RGCs), sequentially generate the diverse cortical excitatory neuronal subtypes that populate different cortical layers. At the end of cortical neurogenesis, the RGCs switch lineages and generate inhibitory olfactory bulb interneurons, and both…
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