NIH R01 · 2024
Research Supplement to Promote Diversity for R01GM145700
ABSTRACT of Parent Award GM145700 Today’s technologies allow profiling thousands of gene expression features for diseases and drugs at a very low cost. This proposal entitled “Virtual Compound Screening Using Gene Expression” aims to develop novel data science approaches to leverage emerging gene expression profiles to discover novel drugs. Previously, we developed a scoring function called RGES to quantify the drug’s potency to reverse disease gene expression based on the drug- and disease- expression profiles. We observed that RGES correlates with drug efficacy. Using this idea, we and others identified drugs that could be repurposed to treat a number of diseases. However, this approach…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.