NIH R01 · 2025
Cerebellar-striatal circuits for control of dopamine activity and food intake
Project Summary Recently, we identified the cerebellum as a novel satiation center in the brain. Yet, little is known about the pathways and circuit mechanisms through which the cerebellum regulates food intake. The major research goal of this proposal is to define cerebellar à striatal circuits that regulate food intake and better understand the physiological changes mediated by activity in this circuit. We have recently identified a subset of molecularly and topographically-distinct neurons in the lateral nucleus of the mouse anterior deep cerebellar nuclei (aDCN-lat) that are activated by food intake (Low et al., 2021). Our functional assessment of these neurons demonstrates that…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.