NIH R01 · 2024
Mechanisms of Lamin A/C-mediated Cardiac Conduction Disorders
PROJECT SUMMARY The cardiac conduction system (CCS) is specialized in the generation and propagation of electrical impulses from the atria to the ventricles to produce a highly coordinated muscle contraction. Cardiac conduction disorders (CCDs) including sick sinus syndrome, atrioventricular block (AVB), and bundle branch block are common arrhythmic disorders that impact the contraction of atria or ventricles. Cardiac pacing is the standard treatment for patients with symptomatic bradyarrhythmia resulting in implantation of over 600,000 pacemakers annually in US due to sinus node dysfunction (SND) or AVB. Currently, there is no alternative treatment for these patients. Thus, understanding…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.