NIH R01 · 2025
Sex-Specific Roles of L-PK in Cholesterol Metabolism and Atherosclerosis
ABSTRACT Liver is the major hub that is responsible for regulating both plasma cholesterol and triglyceride levels as it is involved in their synthesis, secretion, and clearance. Several studies have reported that any errors in these processes will lead to metabolic diseases such as non-alcoholic fatty liver disease and hypercholesterolemia. Hypercholesterolemia will eventually result in atherosclerosis that is the leading cause of death in US. Also, plasma cholesterol and triglyceride levels are highly heritable and several human genome-wide association studies have identified hundreds of genetic loci that could control the levels of these plasma lipids. Unfortunately, only a small number…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.