NIH R01 · 2024
Project Summary/Abstract Understanding how endogenously-generated adult-born neurons functionally integrate into neural circuits may inform strategies employing stem cell-derived neurons to repair damaged brain areas. Olfactory sensory neurons (OSNs), which are generated throughout life in all mammals, provide an ideal model to study functional integration in both the healthy and the regenerating olfactory system. Our long-term goal is to determine how circuit function and regeneration can be enhanced by functional integration of newborn neurons. The overall objective of this application is to determine how evoked activity during an immature developmental window influences OSN survival and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.