NIH R01 · 2025
Novel role of urinary urate in renal cystogenesis and water regulation
PROJECT SUMMARY/ABSTRACT Autosomal Dominant Polycystic Kidney Disease (ADPKD), a genetic disorder leading to progressive renal cyst growth, affects 12 million people globally. Arginine vasopressin (AVP) is a key driver of cystogenesis, and in rodent PKD models, the absence of AVP completely prevents cyst formation. Although V2 receptor (V2R) antagonists effectively inhibit cyst growth, their use is limited by significant polyuria (>6 Liters/day). An alternative strategy involves enhancing renal water reabsorption to suppress central AVP release. Promising approaches include regulating the water channel aquaporin-2 (AQP2) through pathways independent of V2R. The urate transporters GLUT9b and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.