NIH R01 · 2025
PROJECT SUMMARY The establishment of synaptic connectivity during brain development involves the initial formation of an overabundance of synapses followed by a refinement process in which some of these synapses are maintained while others are eliminated. The precise elimination of excess synapses is driven by sensory experience during critical periods of early postnatal life. Impairments in sensory-dependent synapse elimination contribute to neurodevelopmental disorders such as autism, underscoring the importance of this process for the proper development and function of neural circuits. However, although neurodevelopmental disorders are growing in prevalence at an alarming rate,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.