Che Lab

Yale University

PSYCHIATRY

New Haven · United States

NIH-funded
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NIH R01 · 2024

Effects of Early-life Cannabinoid Exposure on Prefrontal Circuitry and Cognitive Behavior across Development

PROJECT SUMMARY Cannabis consumption during pregnancy and lactation has reached 7-15% in pregnant women and nursing mothers in recent years, and will likely rise due to widespread legalization. Increased availability of cannabis has led to the public perception that it is a safe natural remedy for pregnancy-related ailments and postpartum mood disorders. Yet, growing clinical and preclinical data suggest prenatal and perinatal cannabis exposure is associated with long-term neurodevelopmental consequences in children, including sensorimotor, emotional, and cognitive deficits, as well as increased risk for illicit drug use in adolescence and adulthood. The neural mechanisms and sensitive…

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