NIH R01 · 2025
The XPA scaffold protein in Nucleotide Excision Repair
SUMMARY Nucleotide excision repair (NER) protects human cells by removing harmful DNA damage, but repair of damaged DNA by NER can reduce the efficacy of some antitumor drugs such as cisplatin. NER genes are frequently missense mutated in cancers and decreased expression or loss of function mutation of NER genes ERCC1 and ERCC2, respectively, has been shown to correlate with improved patient outcomes after cisplatin treatment. This proposal investigates the hypothesis that reduced NER capacity arising from tumor mutations correlates with greater sensitivity to platinum (Pt) agents. It focuses on the NER scaffolding protein XPA, which is required for proper assembly and organization of the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.