NIH R01 · 2024
Role of Ceramide Regulated Fgf13 in AdiposeT issue Biology
PROJECT SUMMARY/ABSTRACT Dyslipidemia and insulin resistance predispose individuals to development of diabetes, cancer, myocardial infarction, and stroke. A large body of evidence suggests that a class of toxic lipids, termed ceramides, contribute to these metabolic impairments and the ensuing development of these metabolic disorders. Understanding the role of these lipids in the events that drive metabolic diseases holds great promise for developing new therapies to treat these debilitating conditions. We conducted a series of studies ablating the enzymes required for their production in different body locales to discern which tissues were most sensitive to ceramides. These studies…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.