NIH R01 · 2025
Ocular Immune Regulation by Mesenchymal Stem Cells
SUMMARY: This is a competitive renewal application to further define the immunoregulatory function of mesenchymal stem cells (MSCs) in ocular inflammation. Renowned for promoting tissue regeneration and immune quiescence, studies have demonstrated the therapeutic potential of MSCs in human disease. Nevertheless, fundamental questions remain unanswered regarding their immunomodulatory mechanisms. This proposal employs a well characterized transplant model of the murine cornea to systematically investigate how MSCs directly interact with T cells to regulate alloimmunity. Over recent years the work of several laboratories, including our own, has made substantial progress in understanding how…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.