NIH R01 · 2025
Tissue specific immunity to fungal infections
Project summary/abstract Candida albicans is a major opportunistic fungal pathogen of humans, which colonizes mucosal surfaces (oral, gut, vaginal tract) in many individuals and can cause serious systemic (i.e., invasive candidiasis) and mucosal infections (e.g. oropharyngeal candidiasis) in immunocompromised patients. Although it is well established that the oral mucosal and systemic infection niches impose differential immune pressures on C. albicans, the mechanisms by which C. albicans adapts to such distinct environments are still very poorly understood. This proposal is built on the hypothesis, supported by our extensive preliminary data, that C. albicans adaptation and virulence in…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.