NIH R01 · 2024
Contribution of IL6 trans signaling in older females after ischemic stroke
Title: Contribution of IL6 trans signaling in older females after ischemic stroke Abstract: Women have worse outcomes after ischemic stroke than men. Multiple factors influence the outcomes including sex chromosome complement (XX vs. XY), sex hormones (estrogens vs. androgens), and immune responses. IL6 is a key inflammatory cytokine, and higher levels of IL6 are associated with poor stroke outcomes. Downstream signaling after IL6/IL6 receptor interaction is mediated through the JAK/STAT3 pathway. The biological impact of this signaling cascade in aged females after stroke is unknown. Our long-term goal is to dissect sex-dependent molecular mechanisms that regulate IL6/IL6R signaling after…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.