Chaudhary Lab

Research focus

NIH R01 · 2024

Human Intracerebral Hemorrhage: Impact of Hematoma Size, Hemolysis and Iron Overload on Edema and White Matter Survival by MRI

Project Abstract – There is currently no evidence for an established treatment paradigm for intracerebral hemorrhage (ICH). The most recent clinical trials on hematoma evacuation and iron chelator treatment have not shown a significant improvement in neurological function. No objective surrogate markers of disease severity currently exist to guide prognosis. MRI is inherently more informative about local tissue changes following hemorrhage in the brain tissue than CT. We have recently completed our first translational MRI study (R21 - NS099684) validating MRI based evaluation of iron overload in the brain tissue following ICH in 20 patients. We have also demonstrated in another completed…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.