NIH R01 · 2025
ABSTRACT Latinos, one of the largest and fastest growing ethnic groups in the country, face a disproportionate burden of osteoporosis, with over 40% estimated to have low bone mass. The underlying environmental factors contributing to these disparities remain unclear. Per- and polyfluoroalkyl substances (PFAS) are ubiquitous, persistent chemicals and are emerging as potential risk factors for bone toxicity. Animal and autopsy studies have shown that PFAS can accumulate in skeletal tissues, potentially influencing bone metabolism through alterations in osteoclast and osteoblast activities and bone remodeling pathways. However, evidence from human studies is limited, often hindered by small…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.