NIH R01 · 2025
Serine/threonine kinase signaling in beta-lactam resistance of Staphylococcus aureus
Project Abstract: We have identified novel roles of the eukaryotic-like serine/threonine kinase (eSTK) signaling pathway in mediating broad-spectrum β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA). Broad-spectrum β-lactam resistance, which renders most β-lactam drugs therapeutically ineffective, is classically mediated through mecA, the gene that encodes penicillin-binding protein 2a. Broad-spectrum resistance to β-lactams in S. aureus also occurs through non-classical mediators not directly related to mecA. The role played by the non-classical mediators in β-lactam resistance is only superficially understood. Both Stk1 and Stp1 (effectors of eSTK signaling; a…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.