NIH R01 · 2024
PROJECT SUMMARY/ABSTRACT Vitamin D deficiency is common in neonates born preterm and implicated the pathogenesis disease in several organs, such as the lung and retina. In the kidney, vitamin D supplementation clearly prevents the loss of a podocytes in animals with glomerular disease. The podocyte is a terminally differentiated cell vital to the integrity of the glomerular filtration barrier, and podocyte loss leads to chronic kidney disease (CKD). Preterm birth is associated with both increased podocyte loss and CKD. Despite the kidney being a major source for the active form of vitamin D, little is known about either the effect of perinatal vitamin D deficiency on the developing kidney…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.