NIH R01 · 2025
Dysfunctional Renin-Angiotensin System in Septic Shock
Scientific Abstract: Sepsis and septic shock are global healthcare problems associated with mortality rates of up to 40% despite best therapy efforts. Circulating markers of septic shock severity may constitute a clinically relevant approach to individualize therapy and resuscitation for those patients at risk for poor outcomes early in the course of the disease, which may facilitate early and more precise intervention to improve patient outcomes. However, currently used septic shock biomarkers including lactate, may be non-specific, and have variable impacts on prognosis and/or disease management. Activation of the renin-angiotensin-aldosterone system (RAAS) is an early event in septic…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.