NIH R01 · 2024
Targeting brain inflammation and neurocognitive dysfunction in sepsis
PROJECT SUMMARY Sepsis is a serious clinical condition with life-threatening organ dysfunction caused by a dysregulated host response to infection. Up to 70% of septic patients and more than 50% sepsis survivors develop neurocognitive dysfunction, a debilitating condition termed sepsis-associated encephalopathy (SAE). While both clinical and experimental data suggest the role of inflammation in the pathogenesis of SAE, the exact causes and the molecular mechanisms leading to cerebral inflammation and neurocognitive dysfunction are not well understood. We have recently shown that host cellular RNAs including microRNAs are released into the blood circulation during sepsis and that circulating…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.