NIH R01 · 2025
Metabolic dysfunction from ECM remodeling in diseases of human RPE
PROJECT SUMMARY/ABSTRACT The presence of lipid-rich deposits underneath the retinal pigment epithelium (RPE) is a pathologic feature of early age-related macular degeneration (AMD). Drusen development has been associated with RPE lipid metabolism, redox biology and extracellular matrix (ECM) degradation. Mutations in a gene affecting ECM degradation, tissue inhibitor of metalloproteinase 3 (TIMP3), results in a rare inherited retinal degeneration with similar clinical features to AMD, called Sorsby Fundus Dystrophy (SFD). The mechanism by which abnormal ECM turnover influences lipid metabolism and RPE redox resulting in the formation of sub-RPE deposits remains unknown. The goal of this…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.