NIH R01 · 2025
Cellular Senescence and the AKI to CKD transition
PROJECT SUMMARY/ABSTRACT Acute kidney injury (AKI) has a rising incidence among hospitalized patients and the risk for progression to chronic kidney disease (CKD) has been established in both pre-clinical and clinical studies; however, there is still a knowledge gap on the molecular mechanisms driving the AKI to CKD transition. We previously identified Foxm1, a transcription factor considered to be a master regulator of the cell cycle, as having a role in tubular epithelial proliferation in a mouse model of acute ischemic renal injury, Subsequent studies using genetic deletion mouse models demonstrated that Foxm1 is involved in proximal tubular epithelial proliferation after injury in vivo.…
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