Chang Lab

Stanford University

INTERNAL MEDICINE/MEDICINE

Stanford · United States

NIH-funded
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NIH R01 · 2025

Harnessing Big Data to Identify Effective Peripheral Artery Disease Treatments in Chronic Kidney Disease

PROJECT SUMMARY / ABSTRACT Peripheral artery disease (PAD), characterized by diseased arteries to the limbs, affects 200 million people worldwide and 9 million people in the U.S. Chronic kidney disease (CKD) affects 20 million people in the U.S. and confers a markedly higher risk for PAD. Yet patients with CKD are less likely to have revascularization procedures and are more likely to undergo lower extremity amputation than patients without CKD. In addition to a high prevalence of traditional risk factors such as hypertension and diabetes mellitus, patients with CKD have other unique risk factors such as chronic inflammation or uremia, which in turn can lead to more aggressive PAD at a…

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