NIH R01 · 2024
Spore germination pathway in Clostridioides difficile and its pharmacological intervention
ABSTRACT Clostridioides difficile is an anaerobic Gram-positive bacterium that colonizes the gut of patients treated with broad-spectrum antibiotics. A challenge in treating C. difficile infection (CDI) is the production of spores that germinate to active vegetative cells in response to host bile acids. The normal gut microflora typically prevents colonization of C. difficile. Gut microflora dysbiosis as a consequence of treatment with broad-spectrum antibiotics causes recurrence of CDI in 25% of patients, for which spore germination is an instigator. There are no antibiotics for the treatment of multiple recurrent CDI, leading to 11,500 annual deaths in the United States. CDI is the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.