NIH R01 · 2025
Role of DYRK1A/MNB in synaptic growth and function
PROJECT SUMMARY The nervous system fine-tunes synaptic output to ensure reliable communication, partly through kinase-drive protein phosphorylation. Alterations in phosphorylation dynamics profoundly affect neurotransmitter release, synaptic vesicle recycling, synaptic growth and plasticity, and are closely associated with neurodevelopmental and neurodegenerative disorders. The evolutionarily conserved DYRK1A kinase plays a critical role in neurodevelopment and is implicated in several neurological conditions, including autism, Down syndrome, intellectual disabilities, and Alzheimer’s disease. Despite its importance, the precise mechanisms by which DYRK1A regulates synaptic function remain…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.