NIH R01 · 2025
Sculpting Membrane Dynamics: Membrane-Remodeling Factors Shape Oligodendroglial Form and Function
Project Summary Oligodendrocytes in the central nervous system wrap multilamellar compact myelin membranes around axons and dramatically facilitate action potential propagation. Compromised myelination results in neurological deficits in myelin diseases and nervous system injuries. However, myelin sheaths don't look the same. There is vast morphological heterogeneity, and the morphological parameters of myelin sheaths play a key role in determining axon conduction velocity and circuit functions and influencing behavior. Development, plasticity and repair of neural circuits require proper (re)establishment of myelin profiles, which undoubtedly involves extensive membrane remodeling to shape…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.