Chang Lab

University of California, San Diego

PHARMACOLOGY

La Jolla · United States

NIH-funded
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NIH R01 · 2025

MiMA: Mother-infant Metabolite-transporter Atlas

ABSTRACT/SUMMARY The maternal-fetal/infant axis of transport represents one of, if not the highest duration and intimacy of long-distance communication across multi-tissue barriers between two individuals. Transporters enable such communication by controlling the uptake and distribution of metabolites across membranes, tissues, organs, and even between the mother and the infant. Remarkably, only a few hundred human transporters control the exchange of tens of thousands of nutrients and metabolites between different tissue compartments. A comprehensive map of transporters to tissue barriers, and to the substrates (nutrients, metabolites, dietary supplement constituents, xenobiotics, and…

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