NIH R01 · 2024
Encoding of inflammatory mediators by vagal sensory neurons
Project Summary This is the same as the parent award. The nervous system and immune system communicate with each other to respond to infections and maintain immune homeostasis. Work over the last two decades has shown that the vagus nerve is a critical pathway for neuro-immune communication carrying motor signals descending to the body, in addition to sensory signals ascending to the brain. Detection of immune mediators in the periphery, such as cytokines, is thought to be vagally-mediated but it is unclear how sensory neurons respond and represent this information in situ. The goal of the proposed studies is to discover how vagal sensory neurons encode and represent information about…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.