NIH R01 · 2025
Omega 3 Fatty Acids, Acute Neuroprotection Via Mitochondria
Project Summary Neonatal stroke and hypoxia-ischemia (HI) brain injury remains a leading cause of a lifelong neurological handicap. The only currently accepted approach is post-ischemic hypothermia. However, no exact therapeutic mechanisms of this approach are known. A growing body of experimental evidence showed that omega-3 (n-3) fatty acids (FAs) and their bioactive metabolites protect developing brain against HI-reperfusion injury. Using triglyceride emulsions we showed that docosahexaenoic acid (DHA) provided strong neuroprotection against HI brain injury in different rodent models. This neuroprotection was associated with increased DHA content in cerebral mitochondria, preserved…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.