NIH R01 · 2025
Chemical Probes to Study Methionine Redox Biology
Project Summary/Abstract Protein methionine residues are emerging as essential redox sites for physiological processes spanning signal transduction, antioxidant defense, and regulation of protein function. At the same time, aberrant elevations in methionine oxidation induced by oxidative stress and/or inactivation of methionine sulfoxide reductase enzymes can contribute to cancer, neurodegenerative and vascular diseases, and life span. To decipher contributions of methionine redox physiology and pathology, we are developing new chemical reagents to selectively label reactive methionine sites from proteins to proteomes. The scientific premise is that providing access to a modular chemical…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.