NIH R01 · 2024
Regulation of metabolic pathways in NKT cells
ABSTRACT In conventional T cells, signaling pathways that control cellular metabolism have a crucial role in dictating the outcome of T cell activation and their effector function. Resting CD4 and CD8 T cells use predominantly oxidative metabolism but stimulation leads them to sharply increase glucose metabolism and adopt aerobic glycolysis as a primary metabolic program. However, little is known about metabolic regulation and its role for cellular functions of Natural Killer T (NKT) cells although recent studies indicate an important role of metabolism in NKT cell differentiation. NKT cells are a heterogeneous population that shows a high degree of phenotypic and functional specialization.…
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