NIH R01 · 2025
Defining the molecular determinants of inflammatory memory in the pancreas
Project Summary / Abstract Biological systems operate within fluctuating environments, and, therefore, are inherently tasked with accurately responding in real-time to a myriad of signals. Recent evidence suggests that a memory of inflammation can be encoded and retained in the epigenome of cells even following resolution of the initial stimulus. The presence of `inflammatory memory' suggests that preservation of tissue homeostasis also incorporates an evolutionary adaptation in which future responses are educated by past experiences. Inflammation is essential to the disruption of tissue homeostasis, and, in the pancreas, can destabilize the identity of terminally differentiated acinar…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.