NIH R01 · 2024
The nairovirus Crimean-Congo hemorrhagic fever virus (CCHFV) causes severe, lethal hemorrhagic disease. CCHFV is the most prevalent tickborne virus that causes human disease and is endemic in countries across Europe, Asia, and Africa. No FDA-approved countermeasures are currently available for this NIAID priority pathogen. As in other bunyaviruses, the viral M segment of CCHFV encodes the glycoprotein precursor, GPC, which undergoes an especially complicated series of co- and post-translational proteolytic processing steps to generate multiple membrane-anchored, membrane-associated, and secreted glycoproteins. The overarching goal of this highly interwoven collaborative project is to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.