NIH R01 · 2024
Combined antiretroviral therapy (cART) suppresses HIV replication, but 30-60% of infected patients suffer from severe HIV-1 associated neurocognitive disorders (HAND). However, the mechanisms underlying HAND are unclear and this lack of information has prevented the development of effective science-driven treatments. Our data have provided key information connecting etiology, especially by showing that pathogenic contents of plasma extracellular vesicles (EVs) from either chronic SHIV-infected and cART treated rhesus macaque (RM) or HIV(+)–cART treated patients play a key role in the development and progression of HAND. Moreover, our novel findings provide the first evidence that EVs…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.